Domperidone

Product Detailed

 

ProName: EP standard Domperidone CAS 57808-66-9

CasNo: 57808-66-9

Molecular Formula: C22H24ClN5O2

Appearance: White powder

Application: Gastrointestinal Agents

PackAge: 25kg/drum or 1kg/aluminum foil bag

ProductionCapacity: 800 Kilogram/Month

Purity: 99%Min

Sulphated ash: 0.05%

 

Description

Domperidone is a peripherally selective dopamine D2 receptor antagonist is used as an antiemetic, gastroprokinetic agent, and galactagogue.It may be administered orally or rectally, and is available in the form of suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.

 

 

Function

Nausea and vomiting

There is some evidence that domperidone has antiemetic activity.It is recommended in the Canadian Headache Society's guidelines for treatment of nausea associated with acute migraine.

 

Gastroparesis

Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety (feeling full before the meal is finished), abdominal pain and bloating.

 

Domperidone may be useful in diabetic and idiopathic gastroparesis.

However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate (equate) well with relief of symptoms.

 

Parkinson's disease

Parkinson's disease is a chronic neurological condition where a decrease in dopamine in the brain leads to rigidity (stiffness of movement), tremor and other symptoms and signs. Poor gastrointestinal function, nausea and vomiting is a major problem for people with Parkinson's disease because most medications used to treat Parkinson's disease are given by mouth. These medications, such as levodopa can cause nausea as a side effect. Furthermore, anti-nausea drugs, such as metoclopramide, which do cross the blood–brain barrier may worsen theextra-pyramidal symptoms of Parkinson's disease.

 

Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease, because, even though it blocks dopamine receptors (which would be expected to worsen Parkinson's disease), it does not cross theblood–brain barrier (the barrier between the blood circulation of the brain and the rest of the body).In addition to this, domperidone may enhance the bioavailability (effect) of levodopa (one of the main treatments in Parkinson's disease).

Although these features make domperidone a useful drug in Parkinson's disease, caution is needed due to thecardiotoxic side effects of domperidone especially when given intravenously, in elderly people and in high doses (> 30 mg per day). A clinical sign of domperidone's potential toxicity to the heart is the prolongation (lengthening) of the QT interval (a segment of the heart's electrical pattern).

 

Functional dyspepsia

Domperidone may be used in functional dyspepsia in both adults and children

 

 

 

Applications

 

There is some evidence that domperidone has antiemetic activity. It is recommended in the Canadian Headache Society's guidelines for treatment of nausea associated with acute migraine.

Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or a result of abdominal surgery.

Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease; it blocks peripheral D2 receptors but does not cross the blood–brain barrier in normal doses (the barrier between the blood circulation of the brain and the rest of the body) so has no effect on the extrapyramidal symptoms of the disease.

 

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