Cosmetic Ingredients EUK-134 (CAS:81065-76-1)

What Is EUK-134?

EUK-134 is a manganese-salen derivative that has dual antioxidant function i.e. superoxide dismutase and catalase mimetic activities.

Its therapeutic use and studies conducted are based on its property to reduce reactive oxygen species (ROS) induced cellular injury in the body.

It is a  low-molecular-weight synthetic complex that has better potency, stability, and bioavailability than endogenous antioxidant enzymes.

How Does EUK-134 Work?

EUK-134 has superoxide dismutase, SOD, and catalase mimic activity.

SOD converts the superoxide radical into ordinary molecular oxygen and hydrogen peroxide and Catalase decomposes hydrogen peroxidase into water and oxygen. This property of EUK-143 helps neutralize the oxidative stress caused by superoxide radicals and hydrogen peroxide which are reactive oxygen species (ROS) and reduce cellular injury.

At the cellular level during normal biochemical reactions to produce energy in the form of ATP by oxygen metabolism in the mitochondria, a process called oxidative phosphorylation takes place during which ROS are produced as partially reduced byproducts which when present in low amount help in cell signaling and homeostasis. The formation of ROS can also be stimulated by a variety of agents such as UV, pollutants, heavy metals, tobacco, smoke, drugs, xenobiotics, or radiation which are exogenous sources. 

These ROS are highly reactive and are immediately neutralized by a group of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidases (GPxs), thioredoxin (Trx) as well as non-enzymatic antioxidants. When there is an imbalance in this neutralization, the concentration of ROS is increased, and they cause oxidative stress leading to oxidative damage of nucleic acids, proteins, and lipids which can lead to cellular death and tissue injury.

These potentially harmful effects of ROS under oxidative stress have been viewed as an underlying mechanism of aging and a number of diseases, such as ischemia-reperfusion disorders, neurodegenerative disorders, cardiovascular conditions, cancer, and diabetes.

Where To Buy EUK-134?

You can buy EUK-134 solution for cosmetic use from any authorized cosmetic retail store or you can buy them online.

APICDMO can provide the best quality raw materials for EUK-134 in China. We are designed to operate and provide raw materials in large quantities, and our production capacity is 500 kg per month. Our company is SO9001 & ISO14001 certified and has a complete production management system.